This study addresses the challenge of enhancing enzyme stability and regeneration in implantable bioelectrochemical systems. We developed and analyzed dynamic immobilization and renewal strategies using nanostructured carriers and polymer matrices to maintain enzymatic activity. Both experimental and theoretical approaches were employed to evaluate degradation mechanisms and propose mitigation strategies, ensuring sustained catalytic function under physiological conditions. Results demonstrated improved durability and functional retention, offering insights for designing long-lasting, sustainable implantable power sources. These findings underscore the importance of enzyme maintenance in achieving reliable in vivo bioenergy generation.